That defeat was Amorim’s 16th Premier League defeat in 31 matches, and as a result pressure is building on the Portuguese coach.
He is sticking to his principles though, insisting he will stick to his 3-4-2-1 formation that gave him such great success at Sporting.
“No one, not even the Pope will change (my system),” Amorim said.
“This is my job, this is my responsibility, this is my life – so, I will not change that.
“If I’m a player and I have a coach that, with a lot of pressure and (people) all around the world, are saying ‘you need to change the system’, says ‘I’m going to change’, they will look at me in a different way.
“Everything is important when you think about the impact that a decision is going to have on the team.
“I’m doing things my way. I hope to have the time to change but it will be an evolution.”
United welcome Chelsea on Saturday evening, a team that has not won at Old Trafford since May 2013, when Juan Mata scored a late winner against Sir Alex Ferguson’s team.
Matheus Cunha, a player who scored a hat-trick against Chelsea two seasons ago for Wolves, is due to return to the starting line-up after recovering from a hamstring tweak he suffered against Burnley.
That presents more attacking threat, with Bryan Mbeumo largely left to attack by himself at the Etihad but forces club captain Bruno Fernandes into a deeper role.
Amorim again insists that is all part of his plan to “balance the team”.
“I want Bruno to have more possession to try to control the game,” he added.
“Maybe he doesn’t have the same freedom to get inside the box but he is getting there and he can do his shots.
“Sometimes we miss Bruno in front a little bit but if Cunha is there we have an extra player.
“I’m just trying to balance the team and imagine the game and I see Bruno well.
“He’s frustrated because he is not winning and sometimes he likes to go further, but he has a job to do.”