The Blues are without star man Cole Palmer, who has their only Champions League goal so far, so Buonanotte takes up his position in the attacking midfield role.
Joao Pedro is also only fit enough to make the bench, Tyrique George replaces him up front.
Former Benfica man Enzo Fernandez, who Chelsea signed for £107m from the Portugese outfit, captains the side.
Chelsea: Sanchez, Gusto, Chalobah, Badiashile, Cucurella, Caicedo, Fernandez, Neto, Buonanotte, Garnacho, George
